Endogenous TWIST expression and differentiation are opposite during human muscle development

Authors

  • Andrie Koutsoulidou MSc,

    1. Department of Molecular Genetics, Function & Therapy, Cyprus Institute of Neurology and Genetics, P.O.Box 2346, 1683 Nicosia, Cyprus
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  • Nikolaos P. Mastroyiannopoulos PhD,

    1. Department of Molecular Genetics, Function & Therapy, Cyprus Institute of Neurology and Genetics, P.O.Box 2346, 1683 Nicosia, Cyprus
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  • Denis Furling PhD,

    1. UPMC Universitaire Paris 06, UM76, Institut de Myologie, and INSERM, U974 and CNRS, UMR7215, Paris, France
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  • James B. Uney PhD,

    1. Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
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  • Leonidas A. Phylactou PhD

    Corresponding author
    1. Department of Molecular Genetics, Function & Therapy, Cyprus Institute of Neurology and Genetics, P.O.Box 2346, 1683 Nicosia, Cyprus
    • Department of Molecular Genetics, Function & Therapy, Cyprus Institute of Neurology and Genetics, P.O. Box 2346, 1683 Nicosia, Cyprus
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Abstract

TWIST is a transcription factor expressed during early embryonic development. In this study we investigate the expression of TWIST during human muscle development. Human TWIST was found to be endogenously expressed in human fetal myoblasts, and its expression decreased during late stages of development. Myoblasts showed an increasing capacity to differentiate in vitro during development. This inversely proportional relation between TWIST and differentiation capacity of myoblasts suggests that TWIST is involved in the regulation of muscle development. Muscle Nerve, 2011

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