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Keywords:

  • development;
  • differentiation;
  • human fetal stages;
  • myotubes;
  • skeletal muscle;
  • TWIST

Abstract

TWIST is a transcription factor expressed during early embryonic development. In this study we investigate the expression of TWIST during human muscle development. Human TWIST was found to be endogenously expressed in human fetal myoblasts, and its expression decreased during late stages of development. Myoblasts showed an increasing capacity to differentiate in vitro during development. This inversely proportional relation between TWIST and differentiation capacity of myoblasts suggests that TWIST is involved in the regulation of muscle development. Muscle Nerve, 2011