NMDA receptors at the endplate of rat skeletal muscles: Precise postsynaptic localization

Authors

  • Artem I. Malomouzh PhD,

    Corresponding author
    1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia
    • Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia
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  • Leniz F. Nurullin PhD,

    1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia
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  • Svetlana S. Arkhipova PhD,

    1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia
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  • Evgeny E. Nikolsky DSci

    1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, Kazan 420111, Russia
    2. Department of Medical and Biological Physics, Kazan Medical University, Kazan, Russia
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Abstract

In this study we demonstrate expression of the N-methyl-D-aspartate receptor NR1 subunit in the rat neuromuscular junction of skeletal muscles of different functional types (extensor digitorum longus, soleus, and diaphragm muscles) using fluorescence immunocytochemistry. Electron microscopic immunocytochemistry has shown that the NR1 subunit is localized solely on the sarcolemma in the depths of the postsynaptic folds. These findings suggest participation of the glutamatergic signaling system in functioning of the adult mammalian neuromuscular junction. Muscle Nerve, 2011

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