Timing of the administration of suramin treatment after muscle injury
Article first published online: 29 MAY 2012
Copyright © 2012 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 46, Issue 1, pages 70–79, July 2012
How to Cite
Nozaki, M., Ota, S., Terada, S., Li, Y., Uehara, K., Gharaibeh, B., Fu, F. H. and Huard, J. (2012), Timing of the administration of suramin treatment after muscle injury. Muscle Nerve, 46: 70–79. doi: 10.1002/mus.23280
- Issue published online: 12 JUN 2012
- Article first published online: 29 MAY 2012
- Accepted manuscript online: 6 JAN 2012 08:48AM EST
- Manuscript Accepted: 8 DEC 2011
- muscle injury;
It has been reported that suramin treatment can improve muscle healing; however, details about optimizing the dosing requirements remain unclear. The purpose of this study was to determine the optimal timing of suramin administration and investigate the effects it had on the expression of myostatin, follistatin, and muscle vascularity after muscle injury.
Contusion injured muscles of mice were treated with suramin at 1, 2, or 3 weeks post-injury and evaluated histologically and physiologically at 1, 2, and 10 days after injection.
Suramin treatment initiated at 2 weeks post-injury was observed to promote muscle regeneration and muscle strength, and to decrease fibrosis. Suramin reduced myostatin expression and increased follistatin expression and vascularity in injured skeletal muscle.
Suramin's positive effect on muscle regeneration is thought to be due to its enhancement of follistatin expression which increases neoangiogenesis and inhibits myostatin's promotion of fibrosis. Muscle Nerve 46: 70–79, 2012