Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy
Article first published online: 31 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 46, Issue 5, pages 692–697, November 2012
How to Cite
Mano, T., Katsuno, M., Banno, H., Suzuki, K., Suga, N., Hashizume, A., Tanaka, F. and Sobue, G. (2012), Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy. Muscle Nerve, 46: 692–697. doi: 10.1002/mus.23413
- Issue published online: 10 OCT 2012
- Article first published online: 31 AUG 2012
- Accepted manuscript online: 14 APR 2012 06:36AM EST
- Manuscript Accepted: 6 APR 2012
- Center of Excellence (COE) grant, a Grant-in-Aid for Scientific Research on Innovative Areas “Foundation of Synapse and Neurocircuit Pathology,”
- Ministry of Education, Culture, Sports, Science, and Technology of Japan; grants from the Ministry of Health, Labor and Welfare of Japan
- Core Research for Evolutional Science and Technology (CREST) from the Japan Science and Technology Agency (JST)
- androgen receptor;
- motor neuron;
- oxidative stress;
- spinal and bulbar muscular atrophy
Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. The aim of this study was to verify whether urinary 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, is a biomarker for SBMA.
We measured the levels of urinary 8-OHdG in 33 genetically confirmed SBMA patients and 32 age-matched controls over a 24-month period at 6-month intervals.
Urinary 8-OHdG levels in SBMA patients were significantly elevated compared with those of controls and correlated well with motor function scores. During the follow-up period, urinary 8-OHdG levels increased and correlated with motor function at each time-point. In addition, urinary 8-OHdG levels at baseline were correlated with changes in the 6-minute walk test during 24 months.
Urinary 8-OHdG is a biomarker for SBMA, reflecting the severity and possibly predicting the deterioration of motor function. Muscle Nerve, 2012