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Preliminary study of sural nerve morphological changes in uremic hemodialysis patients using 22-MHz high-frequency ultrasound

Authors

  • Mei Wei MD,

    1. Department of Ultrasound, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, Shanghai 200233, China
    2. Department of Ultrasound, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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  • Jiaan Zhu MD, PhD,

    Corresponding author
    1. Department of Ultrasound, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, Shanghai 200233, China
    • Department of Ultrasound, Shanghai Jiaotong University Affiliated Sixth People's Hospital, China Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, Shanghai 200233, China
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  • Niansong Wang PhD, MD,

    1. Department of Ultrasound, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, Shanghai 200233, China
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  • Qing Xue MD,

    1. Department of Ultrasound, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, Shanghai 200233, China
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  • Fang Liu MD,

    1. Department of Ultrasound, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, Shanghai 200233, China
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  • Bing Hu MD,

    1. Department of Ultrasound, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, Shanghai 200233, China
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  • Junchu Fang BD,

    1. Department of Ultrasound, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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  • Yingchun Zhang MD

    1. Department of Ultrasound, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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Abstract

Introduction: The aim of this study was to evaluate the ultrasound (US) morphological changes of sural nerves (SNs) of uremic patients on hemodialysis. Methods: Sixty-six SNs in 33 uremic patients were examined by 22-MHZ high-frequency US and routine nerve conduction studies (NCS), and 76 SNs in 38 controls were also examined. Cross-sectional area (CSA) and maximal fascicular thickness (MFT) of the SNs were measured. Results: The inner parts of the SN were clearly identified in all participants. There were significant increases in CSA and MFT in the patient group (1.86 ± 0.53 mm2 and 0.37 ± 0.08 mm, respectively) compared with the control group (1.38 ± 0.25 mm2 and 0.32 ± 0.03 mm, respectively) (P < 0.001). Fifty-seven SNs (86.36%) had abnormal CSAs, and 51 SNs (77.27%) had abnormal MFTs in the patient group, which was higher than NCS abnormalities (66.67%). Conclusions: A 22-MHZ US can show morphological changes in the SNs of uremic patients and may be a valuable tool. Muscle Nerve, 2012

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