Effect of simvastatin on passive strain-induced skeletal muscle injury in rats

Authors

  • Shaiane Silva Tomazoni MSc,

    Corresponding author
    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, Butantan, São Paulo, SP 05508-900, Brazil
    • Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, Butantan, São Paulo, SP 05508-900, Brazil
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  • Ernesto Cesar Pinto Leal-Junior PhD,

    1. Postgraduate Program in Biophotonics, Health Sciences and Postgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil
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  • Rodney Capp Pallotta MSc,

    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, Butantan, São Paulo, SP 05508-900, Brazil
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  • Vanessa De Godoi MSc,

    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, Butantan, São Paulo, SP 05508-900, Brazil
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  • Rafael Paolo Rossi MSc,

    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, Butantan, São Paulo, SP 05508-900, Brazil
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  • LÚcio Frigo PhD,

    1. Biological Sciences and Health Center, Cruzeiro do Sul University, São Paulo, Brazil
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  • Patrícia Sardinha Leonardo MSc,

    1. Postgraduate Program in Biophotonics, Health Sciences and Postgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil
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  • Patrícia De Almeida BSc,

    1. Postgraduate Program in Biophotonics, Health Sciences and Postgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil
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  • Rodrigo Álvaro Brandão Lopes-Martins PhD

    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 1524, Butantan, São Paulo, SP 05508-900, Brazil
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Abstract

Introduction: HMG-CoA reductase inhibitors are the most frequently prescribed drugs for treatment of lipid imbalance, but they have side effects, such as myopathy. Our aim was to assess the effect of simvastatin on the inflammatory process induced by skeletal muscle injury. Methods: Rats were divided into experimental groups [control group, simvastatin (20 mg/kg) group, group treated with simvastatin (20 mg/kg) and subjected to injury, and group subjected to injury only]. Histological analysis and analyses of creatine kinase activity and C-reactive protein were performed. Results: Animals treated with simvastatin exhibited significantly greater morphological and structural skeletal muscle damage in comparison to the control group and injured animals without treatment. Conclusions: Although simvastatin has a small anti-inflammatory effect in the early stage after a muscle strain injury, the overall picture is negative, as simvastatin increases the extent of damage to muscle morphology. Further studies are needed. Muscle Nerve, 2012

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