Diabetes increases mechanical sensitivity and causes morphological abnormalities in the sural nerve that are prevented by treadmill training
Article first published online: 5 OCT 2012
Copyright © 2012 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 47, Issue 1, pages 46–52, January 2013
How to Cite
Severo Do Nascimento, P., Lovatel, G. A., Ilha, J., Schaan, B. D. and Achaval, M. (2013), Diabetes increases mechanical sensitivity and causes morphological abnormalities in the sural nerve that are prevented by treadmill training. Muscle Nerve, 47: 46–52. doi: 10.1002/mus.23450
- Issue published online: 15 DEC 2012
- Article first published online: 5 OCT 2012
- Accepted manuscript online: 7 MAY 2012 06:56AM EST
- Manuscript Accepted: 1 MAY 2012
- diabetic neuropathy;
- mechanical sensitivity threshold;
- sural nerve morphometry;
- treadmill training
In this investigation we evaluated the effects of treadmill training on mechanical sensitivity and sural nerve morphology in diabetic rats.
Rats were divided into 3 groups: control (C); diabetic (D); and trained diabetic (TD). Training was performed for 8 weeks. Mechanical sensitivity was evaluated using von Frey filaments. Sural nerve analysis included fiber area, diameter, density of myelinated fibers, area occupied by connective tissue, myelin sheath thickness, and g-ratio.
Animals in the D group had a reduced mechanical sensitivity threshold. Morphometric study showed that the D group had a smaller myelinated fiber area and diameter, higher density of fibers and area occupied by connective tissue, thinner myelin sheath, and higher g-ratio. The D group had a higher percentage of small myelinated fibers and a lower percentage of large-diameter myelinated fibers than the C and TD groups.
Training prevents functional and morphological abnormalities in the sural nerve caused by diabetes. Muscle Nerve, 2013