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Diabetes increases mechanical sensitivity and causes morphological abnormalities in the sural nerve that are prevented by treadmill training

Authors

  • Patrícia Severo Do Nascimento PT, MSc,

    1. Programa de Pós-Graduaç˜o em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    2. Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Porto Alegre 90050-170, Brazil
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  • Gisele Agustini Lovatel PT, MSc,

    1. Programa de Pós-Graduaç˜o em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
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  • Jocemar Ilha PT, PhD,

    1. Programa de Pós-Graduaç˜o em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    2. Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Porto Alegre 90050-170, Brazil
    3. Departamento de Fisioterapia, Universidade do Estado de Santa Catarina, Santa Maria, Brazil
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  • Beatriz D'agord Schaan MD, PhD,

    1. Programa de Pós-Graduaç˜o em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    2. Departamento de Medicina Interna, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul e Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
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  • Matilde Achaval MD, PhD

    Corresponding author
    1. Programa de Pós-Graduaç˜o em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    2. Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Porto Alegre 90050-170, Brazil
    • Programa de Pós-Graduaç˜o em Neurocîncias, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Abstract

Introduction:

In this investigation we evaluated the effects of treadmill training on mechanical sensitivity and sural nerve morphology in diabetic rats.

Methods:

Rats were divided into 3 groups: control (C); diabetic (D); and trained diabetic (TD). Training was performed for 8 weeks. Mechanical sensitivity was evaluated using von Frey filaments. Sural nerve analysis included fiber area, diameter, density of myelinated fibers, area occupied by connective tissue, myelin sheath thickness, and g-ratio.

Results:

Animals in the D group had a reduced mechanical sensitivity threshold. Morphometric study showed that the D group had a smaller myelinated fiber area and diameter, higher density of fibers and area occupied by connective tissue, thinner myelin sheath, and higher g-ratio. The D group had a higher percentage of small myelinated fibers and a lower percentage of large-diameter myelinated fibers than the C and TD groups.

Conclusion:

Training prevents functional and morphological abnormalities in the sural nerve caused by diabetes. Muscle Nerve, 2013

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