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Near-infrared spectroscopy during exercise and recovery in children with juvenile dermatomyositis

Authors

  • G. Esther A. Habers MSc,

    1. Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB.02.056.0, P.O. Box 85090, NL-3508 AB Utrecht, The Netherlands
    2. Faculty of Human Movement Sciences, VU University, Amsterdam, The Netherlands
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  • Rogier De Knikker MSc,

    1. Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB.02.056.0, P.O. Box 85090, NL-3508 AB Utrecht, The Netherlands
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  • Marco Van Brussel PhD,

    1. Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB.02.056.0, P.O. Box 85090, NL-3508 AB Utrecht, The Netherlands
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  • Erik Hulzebos PhD,

    1. Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB.02.056.0, P.O. Box 85090, NL-3508 AB Utrecht, The Netherlands
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  • Dick F. Stegeman PhD,

    1. Faculty of Human Movement Sciences, VU University, Amsterdam, The Netherlands
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  • Annet Van Royen MD, PhD,

    1. Department of Pediatric Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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  • Tim Takken PhD

    Corresponding author
    1. Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB.02.056.0, P.O. Box 85090, NL-3508 AB Utrecht, The Netherlands
    • Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB.02.056.0, P.O. Box 85090, NL-3508 AB Utrecht, The Netherlands

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Abstract

Introduction: We hypothesized that microvascular disturbances in muscle tissue play a role in the reduced exercise capacity in juvenile dermatomyositis (JDM). Methods: Children with JDM, children with juvenile idiopathic arthritis (clinical controls), and healthy children performed a maximal incremental cycloergometric test from which normalized concentration changes in oxygenated hemoglobin (Δ[O2Hb]) and total hemoglobin (Δ[tHb]) as well as the half-recovery times of both signals were determined from the vastus medialis and vastus lateralis muscles using near-infrared spectroscopy. Results: Children with JDM had lower Δ[tHb] values in the vastus medialis at work rates of 25%, 50%, 75%, and 100% of maximal compared with healthy children; the increase in Δ[tHb] with increasing intensity seen in healthy children was absent in children with JDM. Other outcome measures did not differ by group. Conclusions: The results suggest that children with JDM may experience difficulties in increasing muscle blood volume with more strenuous exercise. Muscle Nerve, 2013

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