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Tongue muscle plasticity following hypoglossal nerve stimulation in aged rats

Authors

  • Nadine P. Connor PhD,

    Corresponding author
    1. Department of Surgery, Otolaryngology–Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA
    2. Department of Communicative Disorders, University of Wisconsin, Madison, Wisconsin, USA
    • Department of Surgery, Otolaryngology–Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA
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  • John A. Russell MS,

    1. Department of Surgery, Otolaryngology–Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA
    2. Department of Communicative Disorders, University of Wisconsin, Madison, Wisconsin, USA
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  • Michelle A. Jackson MS,

    1. University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
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  • Heidi Kletzien BS,

    1. Department of Surgery, Otolaryngology–Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA
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  • Hao Wang MD, PhD,

    1. Department of Surgery, Otolaryngology–Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA
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  • Allison J. Schaser MS,

    1. Department of Surgery, Otolaryngology–Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA
    2. Department of Communicative Disorders, University of Wisconsin, Madison, Wisconsin, USA
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  • Glen E. Leverson PhD,

    1. Department of Surgery, Otolaryngology–Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA
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  • David L. Zealear PhD

    1. Department of Otolaryngology–Head and Neck Surgery, Vanderbilt University, Nashville, Tennessee, USA
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Abstract

Introduction: Age-related decreases in tongue muscle mass and strength have been reported. It may be possible to prevent age-related tongue muscle changes using neuromuscular electrical stimulation (NMES). Our hypothesis was that alterations in muscle contractile properties and myosin heavy chain composition would be found after NMES. Methods: Fifty-four young, middle-aged, and old 344/Brown Norway rats were included in this study. Twenty-four rats underwent bilateral electrical stimulation of the hypoglossal nerves for 8 weeks and were compared with control or sham rats. Muscle contractile properties and myosin heavy chain (MHC) in the genioglossus (GG), styloglossus (SG), and hyoglossus (HG) muscles were examined. Results: Compared with unstimulated control rats, we found reduced muscle fatigue, increased contraction and half-decay times, and increased twitch and tetanic tension. Increased type I MHC was found, except for in GG in old and middle-aged rats. Conclusion: Transitions in tongue muscle contractile properties and phenotype were found after NMES. Muscle Nerve, 2013

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