Disclosure: The U.S. Patent and Trademark Office awarded the General Hospital Corporation (Boston, MA) a patent for the ATLIS™ device in 2009.
Developing normalized strength scores for neuromuscular research†
Article first published online: 21 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 47, Issue 2, pages 177–182, February 2013
How to Cite
Andres, P. L., English, R., Mendoza, M., Florence, J., Malkus, E., Schierbecker, J., Siener, C., Malspeis, S., Schoenfeld, D. A., Munsat, T. L. and Cudkowicz, M. E. (2013), Developing normalized strength scores for neuromuscular research. Muscle Nerve, 47: 177–182. doi: 10.1002/mus.23516
- Issue published online: 24 JAN 2013
- Article first published online: 21 NOV 2012
- Accepted manuscript online: 12 JUL 2012 08:04AM EST
- Manuscript Accepted: 3 JUL 2012
- outcomes measures;
- strength testing;
- summary scores
Introduction: The Accurate Test of Limb Isometric Strength (ATLIS) device can reliably measure the strength of 12 muscle groups using a fixed load cell. The purpose of this study was to analyze ATLIS data from healthy adults to calculate an individual's predicted strength scores. Methods: ATLIS data were collected from 432 healthy adults. Linear regression models were developed to predict each muscle group's strength. The R-squared statistic assessed variability accounted for by the models. Results: Simple main effects models stratified by gender were used to establish regression equations for each muscle using factors of age, weight, and height. Conclusions: Normalizing raw strength scores controls for biometric factors, thus enabling meaningful comparisons between subjects and allowing each muscle to contribute equally to a summary score. Normalized scores are easily interpreted for broad clinical uses, and derived summary scores establish individuals' disease progression rates using a common scale, allowing for more efficient clinical trials. Muscle Nerve, 2013