Shock wave treatment improves nerve regeneration in the rat

Authors

  • Siegfried Mense MD, PhD,

    Corresponding author
    • Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Ruprecht Karls University Heidelberg, 68167, Mannheim, Germany
    Search for more papers by this author
  • Ulrich Hoheisel MD

    1. Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Ruprecht Karls University Heidelberg, 68167, Mannheim, Germany
    Search for more papers by this author

Correspondence to: S. Mense; e-mail: siegfried.mense@medma.uni-heidelberg.de

Abstract

Introduction: The aims of the experiments were to: (1) determine whether low-energy shock wave treatment accelerates the recovery of muscle sensitivity and functionality after a nerve lesion; and (2) assess the effect of shock waves on the regeneration of injured nerve fibers. Methods: After compression of a muscle nerve in rats the effects of shock wave treatment on the sequelae of the lesion were tested. In non-anesthetized animals, pressure pain thresholds and exploratory activity were determined. The influence of the treatment on the distance of nerve regeneration was studied in immunohistochemical experiments. Results: Both behavioral and immunohistochemical data show that shock wave treatment accelerates the recovery of muscle sensitivity and functionality and promotes regeneration of injured nerve fibers. Conclusion: Treatment with focused shock waves induces an improvement of nerve regeneration in a rodent model of nerve compression. Muscle Nerve 47: 702–710, 2013

Ancillary