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Research Article
Shock wave treatment improves nerve regeneration in the rat
Article first published online: 16 MAR 2013
DOI: 10.1002/mus.23631
Copyright © 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Mense, S. and Hoheisel, U. (2013), Shock wave treatment improves nerve regeneration in the rat. Muscle Nerve, 47: 702–710. doi: 10.1002/mus.23631
Publication History
- Issue published online: 22 APR 2013
- Article first published online: 16 MAR 2013
- Accepted manuscript online: 16 AUG 2012 11:46PM EST
- Manuscript Accepted: 12 AUG 2012
- Abstract
- Article
- References
- Cited By
Keywords:
- focused shock waves;
- muscle;
- nerve regeneration;
- pain-related behavior;
- PGP 9.5 immunohistochemistry
Introduction: The aims of the experiments were to: (1) determine whether low-energy shock wave treatment accelerates the recovery of muscle sensitivity and functionality after a nerve lesion; and (2) assess the effect of shock waves on the regeneration of injured nerve fibers. Methods: After compression of a muscle nerve in rats the effects of shock wave treatment on the sequelae of the lesion were tested. In non-anesthetized animals, pressure pain thresholds and exploratory activity were determined. The influence of the treatment on the distance of nerve regeneration was studied in immunohistochemical experiments. Results: Both behavioral and immunohistochemical data show that shock wave treatment accelerates the recovery of muscle sensitivity and functionality and promotes regeneration of injured nerve fibers. Conclusion: Treatment with focused shock waves induces an improvement of nerve regeneration in a rodent model of nerve compression. Muscle Nerve 47: 702–710, 2013