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Keywords:

  • focused shock waves;
  • muscle;
  • nerve regeneration;
  • pain-related behavior;
  • PGP 9.5 immunohistochemistry

Introduction: The aims of the experiments were to: (1) determine whether low-energy shock wave treatment accelerates the recovery of muscle sensitivity and functionality after a nerve lesion; and (2) assess the effect of shock waves on the regeneration of injured nerve fibers. Methods: After compression of a muscle nerve in rats the effects of shock wave treatment on the sequelae of the lesion were tested. In non-anesthetized animals, pressure pain thresholds and exploratory activity were determined. The influence of the treatment on the distance of nerve regeneration was studied in immunohistochemical experiments. Results: Both behavioral and immunohistochemical data show that shock wave treatment accelerates the recovery of muscle sensitivity and functionality and promotes regeneration of injured nerve fibers. Conclusion: Treatment with focused shock waves induces an improvement of nerve regeneration in a rodent model of nerve compression. Muscle Nerve 47: 702–710, 2013