Role of repeat skeletal muscle biopsy: How useful is it?
Version of Record online: 21 APR 2013
Copyright © 2012 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 47, Issue 6, pages 835–839, June 2013
How to Cite
Goutman, S. A. and Prayson, R. A. (2013), Role of repeat skeletal muscle biopsy: How useful is it?. Muscle Nerve, 47: 835–839. doi: 10.1002/mus.23697
- Issue online: 23 MAY 2013
- Version of Record online: 21 APR 2013
- Accepted manuscript online: 7 NOV 2012 05:07AM EST
- Manuscript Accepted: 4 OCT 2012
- diagnostic yield;
- muscle biopsy;
- repeat muscle biopsy;
- skeletal muscle biopsy;
Introduction: The role of skeletal muscle biopsy is established; however, to our knowledge, no study has systematically evaluated the utility of a repeat biopsy. Methods: This study was a retrospective clinicopathologic review of 66 patients (mean age 38.1 years, 39 men) with at least 1 repeat muscle biopsy obtained between February 1992 and November 2011. Clinical data determined how results of the subsequent biopsy impacted patient management. Results: Repeat biopsy yielded a definitive diagnosis in 16 of 66 patients (24%). In the remaining patients, a repeat study provided clinically useful information or directly answered the clinical question (n = 30, 45%) by excluding a differential consideration (n = 19), supporting treatment continuation (n = 8), prompting treatment change (n = 1), confirming the original diagnosis (n = 1), or establishing a likely diagnosis (n = 1). Conclusion: Repeat muscle biopsy plays a role in the evaluation of patients with suspected myopathy in certain clinical circumstances. Muscle Nerve 47: 835–839, 2013