• ClC-1;
  • Nav1.4;
  • myotonia congenita;
  • warm-up phenomenon;
  • sodium-channel slow-inactivation

Myotonia is a heritable disorder in which patients are unable to willfully relax their muscles. The physiological basis for myotonia lies in well-established deficiencies of skeletal muscle chloride and sodium conductances. What is unclear is how normal muscle function can temporarily return with repeated movement, the so-called “warm-up” phenomenon. Electrophysiological analyses of the skeletal muscle voltage-gated sodium channel Nav1.4 (gene name SCN4A), a key player in myotonia, have revealed several parallels between the Nav1.4 biophysical signature, specifically slow-inactivation, and myotonic warm-up, which suggest that Nav1.4 is critical not only in producing the myotonic reaction, but also in mediating the warm-up. Muscle Nerve, 2013