Supported by the National Multiple Sclerosis Society (FG 1892A1/1), the National Center for Research Resources (P41-RR14075), a pilot grant from the Harvard NeuroDiscovery Center, a fellowship grant from the American Academy of Neurology, and a training grant from the Muscular Dystrophy Association.
7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis
Article first published online: 29 MAR 2013
Copyright © 2012 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 47, Issue 5, pages 760–762, May 2013
How to Cite
Cohen-Adad, J., Zhao, W., Keil, B., Ratai, E.-M., Triantafyllou, C., Lawson, R., Dheel, C., Wald, L. L., Rosen, B. R., Cudkowicz, M. and Atassi, N. (2013), 7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis. Muscle Nerve, 47: 760–762. doi: 10.1002/mus.23720
- Issue published online: 22 APR 2013
- Article first published online: 29 MAR 2013
- Accepted manuscript online: 13 NOV 2012 10:53PM EST
- Manuscript Accepted: 6 NOV 2012
- amyotrophic lateral sclerosis;
- spinal cord;
- ultra-high field
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting lower and upper motor neurons. Degeneration of the lateral corticospinal tract (CST) is a key finding in ALS cervical spinal cord autopsies. We hypothesized that in vivo ultra-high-field MRI of the cervical spinal cord can detect abnormality in the CST. Methods: A patient with ALS (disease duration 23 months) and a healthy control were scanned at 7-T MRI using a 19-channel coil. Multi-echo -weighted imaging was performed in the spinal cord, covering C2–C6. Cross-sectional resolution was 0.37 × 0.37 mm2. Results: We detected clear signal hyperintensity in both segments of the lateral CST in the ALS patient, which was significant when compared with the normal control subject (P < 10−7). Conclusion: We believe there are potential benefits of 7-T MRI for increased sensitivity and spatial accuracy in characterizing pathology in the spinal cord. Muscle Nerve 47: 760–762, 2013