This study was supported by the National Institutes of Health (AA-11431, AA-12908, and K24-AA-16126) and by a special fund from Rhode Island Hospital.
Experimental model of alcohol-related peripheral neuropathy
Version of Record online: 13 JUN 2013
© 2013 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 48, Issue 2, pages 204–211, August 2013
How to Cite
Mellion, M. L., Nguyen, V., Tong, M., Gilchrist, J. and De La Monte, S. (2013), Experimental model of alcohol-related peripheral neuropathy. Muscle Nerve, 48: 204–211. doi: 10.1002/mus.23744
- Issue online: 23 JUL 2013
- Version of Record online: 13 JUN 2013
- Accepted manuscript online: 2 DEC 2012 01:56AM EST
- Manuscript Accepted: 28 NOV 2012
- National Institutes of Health. Grant Numbers: AA-11431, AA-12908, K24-AA-16126
- chronic ethanol exposure;
- nerve conduction study;
- rat model
The aim of this work was to determine the effect of chronic alcohol exposure on peripheral nerves in a nutritionally balanced rat model of alcoholism.
Three different strains of adult male rats were pair-fed for 8 weeks with isocaloric liquid diets containing 0% or 37% ethanol. Nerve conduction studies (NCS) were performed. Peripheral nerve and muscle were examined histologically with morphometrics.
Ethanol exposure significantly slowed velocity in tibial and fibular nerves, but not in the plantar nerve in all 3 strains. Studies of the sciatic nerve revealed decreased fiber diameters and increased regenerative sprouts in peripheral nerves. There was muscle denervation of ethanol-exposed rats in all 3 strains.
Chronic ethanol exposure caused a polyneuropathy characterized by axonal degeneration despite adequate nutrition. These results suggest that ethanol exposure has direct neurotoxic effects on peripheral nerves. This model may be useful in understanding the underlying mechanism(s) of alcohol-related peripheral neuropathy. Muscle Nerve, 48: 204–211, 2013