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Guillain–Barré syndrome during childhood: Particular clinical and electrophysiological features

Authors

  • David Devos MD,

    1. Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
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  • Armelle Magot MD,

    1. Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
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  • Julie Perrier-Boeswillwald MD,

    1. Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
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  • Guillemette Fayet MD, PHD,

    1. Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
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  • Laurene Leclair-Visonneau MD,

    1. Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
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  • Yolaine Ollivier MD,

    1. Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
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  • Sylvie Nguyen The Tich MD, PHD,

    1. Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
    Current affiliation:
    1. Service de Neuropédiatrie, CHU, Angers, France
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  • Yann Pereon MD, PHD

    Corresponding author
    • Centre de Référence Maladies Neuromusculaires Nantes–Angers, Laboratoire d'Explorations Fonctionnelles, Nantes cedex, France
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Correspondence to: Y. Péréon; e-mail: yann.pereon@univ-nantes.fr

ABSTRACT

Introduction

Guillain–Barré syndrome (GBS) has some specific characteristics in children.

Methods

In this study we reviewed the clinical, laboratory, electrophysiological, and prognosis features of the 19 children diagnosed with GBS at Nantes University Hospital from 2000 to 2011.

Results

Gait disturbance and leg pain were the most frequent presenting symptoms. Electrophysiological examinations revealed significant abnormalities even when performed within the first week after onset. Decreased distal CMAP amplitude was noted in 89% of cases. The pattern indicated an acute inflammatory demyelinating polyneuropathy in 95% of cases and acute motor axonal neuropathy in the remaining 5%. About two-thirds of the children were treated with intravenous immunoglobulin. After >1 year of follow-up, 17 patients had complete recovery.

Conclusion

Gait disorder, leg pain, a high rate of distal conduction block, and a good prognosis are among the main specific features of GBS in childhood. Muscle Nerve, 48: 247–251, 2013

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