Effect of different approaches to target force on transcranial magnetic stimulation responses

Authors


  • This study was supported by a grant for research on the brain during exercise from the Fonds de Dotation Recherche en Santé Respiratoire, appel d'offres 2011 (to M.G.) and a doctoral research grant from the Rhône-Alpes Region (to J.T.).

Correspondence to: V. Samuel, Laboratoire HP2 (U1042 INSERM), UF Recherche sur l'Exercice, Hôpital Sud, Avenue Kimberley, 38 434 Echirolles, France; e-mail: sverges@chu-grenoble.fr

ABSTRACT

Introduction: The aim of this study was to determine whether the manner in which a target force is approached can influence the electromyographic (EMG) and mechanical parameters evoked by transcranial magnetic stimulation (TMS) during brief muscle contractions. Methods: The amplitude of motor-evoked potentials (MEP) and superimposed twitch and the duration of the silent period were recorded in 8 healthy participants in response to TMS delivered during brief isometric voluntary contractions of the quadriceps maintaining a target force (10% and 50% of maximal voluntary force) or gradually increasing or decreasing to reach this point. Results: MEP and superimposed twitch, unlike the silent period, are influenced by the manner of reaching a low force. Conclusions: Clear instructions must be provided to research participants and patients. Rapidly increasing to a target force without exceeding it and maintaining the force before the delivery of TMS results in stable, representative MEP amplitudes. Muscle Nerve 48: 430–432, 2013

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