Motor unit loss and weakness in association with diabetic neuropathy in humans
This work was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada. M.D.A. was supported by the Ontario Graduate Scholarship (OGS) program. The authors have no conflicts of interest to disclose. Supported by the National Science and Engineering Research Council of Canada.
Correspondence to: M. Allen; e-mail: firstname.lastname@example.org
Diabetes mellitus can be associated with peripheral neuropathy which may affect numbers of functioning motor units (MUs) of limb muscles. Direct quantitative assessment of MU numbers and muscle strength have not been performed in humans. We compared the estimated number of MUs of individuals with diabetic polyneuropathy (DPN) versus controls.
Patients with signs/symptoms of DPN were studied using decomposition-enhanced quantitative electromyography of the tibialis anterior (TA). Motor unit number estimates were derived from this analysis.
Dorsiflexion strength was ∼60% less in DPN than controls (P < 0.05). Additionally, the estimated number of functioning TA MUs was ∼60% fewer in patients with DM (∼46) versus controls (∼111) (P < 0.05).
These data directly measure MU loss associated with DPN in a proximal muscle in humans. It remains to be determined whether quantifying MU loss has clinical utility in monitoring the progression or management of DPN. Muscle Nerve, 48: 298–300, 2013