The first 2 authors (J.R.D. and L.G.V.) contributed equally to this study.
A pilot study of muscle plasma protein changes after exercise
Article first published online: 30 AUG 2013
Copyright © 2013 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 49, Issue 2, pages 261–266, February 2014
How to Cite
Dahlqvist, J. R., Voss, L. G., Lauridsen, T., Krag, T. O. and Vissing, J. (2014), A pilot study of muscle plasma protein changes after exercise. Muscle Nerve, 49: 261–266. doi: 10.1002/mus.23909
Disclosure: J.V. has received research grants and travel scholarships from Genzyme Corporation, and is a member of Genzyme's Global Advisory Board for Pompe disease. He acts as a research adviser for Cardoz AB and Lundbeck A/S.
- Issue published online: 16 JAN 2014
- Article first published online: 30 AUG 2013
- Accepted manuscript online: 28 MAY 2013 09:58PM EST
- Manuscript Accepted: 13 MAY 2013
- The Sara and Ludvig Elsass Foundation
- creatine kinase;
- exercise-induced muscle damage;
- skeletal troponin I;
Introduction: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage. Methods: Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects. Results: Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time. Conclusions: Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage. Muscle Nerve 49: 261–266, 2014