Association between structural and functional corticospinal involvement in amyotrophic lateral sclerosis assessed by diffusion tensor MRI and triple stimulation technique

Authors

  • Aude-Marie Grapperon MD,

    1. Department of Neurology and Neuromuscular Diseases, CHU La Timone, Marseille, France
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  • Annie Verschueren MD,

    1. Department of Neurology and Neuromuscular Diseases, CHU La Timone, Marseille, France
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  • Yann Duclos PhD,

    1. Department of Neurology and Neuromuscular Diseases, CHU La Timone, Marseille, France
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  • Sylviane Confort-Gouny PhD,

    1. Biological and Medical Magnetic Resonance Center (CRMBM) and Center for Metabolic Exploration using Magnetic Resonance (CEMEREM) (UMR 7339), CHU La Timone, Marseilles, France
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  • Elisabeth Soulier MS,

    1. Biological and Medical Magnetic Resonance Center (CRMBM) and Center for Metabolic Exploration using Magnetic Resonance (CEMEREM) (UMR 7339), CHU La Timone, Marseilles, France
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  • Anderson D. Loundou PhD,

    1. Department of Methodological Aid to Clinical Research, CHU La Timone, Marseilles, France
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  • Maxime Guye MD, PhD,

    1. Biological and Medical Magnetic Resonance Center (CRMBM) and Center for Metabolic Exploration using Magnetic Resonance (CEMEREM) (UMR 7339), CHU La Timone, Marseilles, France
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  • Patrick J. Cozzone PhD,

    1. Biological and Medical Magnetic Resonance Center (CRMBM) and Center for Metabolic Exploration using Magnetic Resonance (CEMEREM) (UMR 7339), CHU La Timone, Marseilles, France
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  • Jean Pouget MD,

    1. Department of Neurology and Neuromuscular Diseases, CHU La Timone, Marseille, France
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  • Jean-Philippe Ranjeva PhD,

    1. Biological and Medical Magnetic Resonance Center (CRMBM) and Center for Metabolic Exploration using Magnetic Resonance (CEMEREM) (UMR 7339), CHU La Timone, Marseilles, France
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    • Drs. Ranjeva and Attarian contributed equally to this work.

  • Shahram Attarian MD, PhD

    Corresponding author
    1. Department of Neurology and Neuromuscular Diseases, CHU La Timone, Marseille, France
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    • Drs. Ranjeva and Attarian contributed equally to this work.


ABSTRACT

Introduction: We investigated the functional and structural integrity of the corticospinal tract (CST) using diffusion tensor imaging (DTI) and the triple stimulation technique (TST) in patients with amyotrophic lateral sclerosis (ALS). Methods: Fourteen patients with ALS, 13 healthy controls (HCs), and 6 patients with lower motor neuron (LMN) syndrome underwent DTI and TST. Results: The mean diffusivity was higher in ALS patients than HCs (P < 0.01). The TST ratio was lower in ALS patients compared with HCs (P < 0.001) and in LMN patients compared with HCs (P < 0.05). The increase in the mean diffusivity was correlated with the decrease in the TST ratio (P < 0.01). Conclusions: Significant correlations exist between the DTI and TST results, indicating both structural and functional involvement of the CST in patients with ALS. Muscle Nerve 49:551–557, 2014

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