Comparison of sensitivity and specificity among 15 criteria for chronic inflammatory demyelinating polyneuropathy


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  • This study was supported by the National Center for Advancing Translational Sciences, National Institutes of Health (UL1 TR000040) and the Michael D. Rothman CIDP Research Fund.

  • Disclosure: The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.


Introduction: There have been 15 formal sets of criteria published for the diagnosis of CIDP. No study to date has compared the sensitivity and specificity of all published criteria in the same patient population. Methods: We conducted a retrospective chart review of patients with CIDP (n = 56) and controls with diabetic polyneuropathy (n = 37) or amyotrophic lateral sclerosis (n = 39) who were followed in an academic neuromuscular practice. The sensitivity and specificity of each CIDP criterion was calculated, including clinical, laboratory, and electrodiagnostic components. Results: Sensitivities ranged from 1.8% to 87.5%; the Dyck (87.5%), Neuropathy Association (75%), and European Federation of Neurological Societies (EFNS; 73.2%) criteria ranked highest. Specificities ranged from 65.6% to 100% and, among the 3 most sensitive criteria, the EFNS (90.8%) and Neuropathy Association (82.9%) criteria were most specific. Conclusions: In our patient population, the EFNS and Neuropathy Association criteria stand out due to high sensitivity and specificity. Muscle Nerve 50: 40–46, 2014