Magnetic resonance imaging phenotyping of Becker muscular dystrophy

Authors

  • Neda Faridian-Aragh MD,

    1. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
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  • Kathryn R. Wagner MD, PhD,

    1. Center for Genetic Muscle Disorders, Kennedy Krieger Institute, Baltimore, Maryland, USA
    2. Department of Neurology and Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    3. Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
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  • Doris G. Leung MD,

    1. Center for Genetic Muscle Disorders, Kennedy Krieger Institute, Baltimore, Maryland, USA
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  • John A. Carrino MD, MPH

    Corresponding author
    1. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
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  • Disclosure: J.A.C. serves as a research consultant for General Electric Corporation.

  • This study was supported by research grants from Siemens AG and Carestream Health, Inc. (to J.A.C.).

ABSTRACT

Introduction: There is little information on magnetic resonance imaging (MRI) phenotypes of Becker muscular dystrophy (BMD). This study presents the MRI phenotyping of the upper and lower extremities of a large cohort of BMD patients. Methods: In this retrospective study, MRI images of 33 BMD subjects were evaluated for severity, distribution, and symmetry of involvement. Results: Teres major, triceps long head, biceps brachii long head, gluteus maximus, gluteus medius, vasti, adductor longus, adductor magnus, semitendinosus, semimembranosus, and biceps femoris muscles showed the highest severity and frequency of involvement. All analyzed muscles had a high frequency of symmetric involvement. There was significant variability of involvement between muscles within some muscle groups, most notably the arm abductors, posterior arm muscles, medial thigh muscles, and lateral hip rotators. Conclusions: This study showed a distinctive pattern of involvement of extremity muscles in BMD subjects. Muscle Nerve 50: 962–967, 2014

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