Electrodiagnostic findings in acute porphyric neuropathy

Authors

  • Dr. James W. Albers MD, Phd,

    1. Electromyography Laboratory, Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester
    Current affiliation:
    1. Department of Neurology, The Medical College of Wisconsin, Milwaukee, WI
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  • Dr. William C. Robertson Jr. MD,

    1. Electromyography Laboratory, Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester
    Current affiliation:
    1. Department of Neurology, University of Wisconsin Medical School, Madison, WI
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  • Dr. Jasper R. Daube MD

    Corresponding author
    1. Electromyography Laboratory, Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester
    • Electromyography Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN 55901
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Abstract

Of 115 patients with acute intermittent porphyria seen during a 20-year period, 11 had experienced an acute episode of quadriparesis. Nerve conduction studies performed on 8 of these 11 patients showed lowamplitude compound action potentials and normal velocity measurements. Needle electromyography demonstrated prominent fibrillation potentials, especially in proximal muscles. The changes in these findings with time confirm that this disorder is an acute axonal neuropathy.

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