Muscle function in rheumatic disease patients treated with corticosteroids
Version of Record online: 13 OCT 2004
Copyright © 1983 John Wiley & Sons, Inc.
Muscle & Nerve
Volume 6, Issue 2, pages 128–135, February 1983
How to Cite
Rothstein, J. M., Delitto, A., Sinacore, D. R. and Rose, S. J. (1983), Muscle function in rheumatic disease patients treated with corticosteroids. Muscle Nerve, 6: 128–135. doi: 10.1002/mus.880060208
- Issue online: 13 OCT 2004
- Version of Record online: 13 OCT 2004
- Manuscript Accepted: 13 OCT 1982
- Manuscript Received: 8 MAR 1982
Clinical and experimental data indicate that long-term corticosteroid use leads to atrophy of the type 2 muscle fibers. The purpose of this study was to characterize and quantify the nature of muscle function in rheumatic disease patients who have been on long-term corticosteroid therapy. Quadriceps function (i.e., peak torque and power) in 19 patients (11 with rheumatoid arthritis, five with systemic lupus erythematosis, and 3 other) and 11 age- and activity-matched normal controls was measured with an isokinetic dynamometer (Cybex II), during four constant velocity movements. Power was significantly lower for the patients at all speeds. At the higher speeds the patients' deficit in power production increased as indicated by a difference in the slopes of power-velocity regression lines. Measures of peak torque could not be consistently used to differentiate the groups. Patients with rheumatic diseases receiving corticosteroids have a decreased ability to generate muscle power. The method described allows for quantification of these deficits in a clinical setting.