Age-related differences in absolute numbers of skeletal muscle satellite cells
Version of Record online: 13 OCT 2004
Copyright © 1983 John Wiley & Sons, Inc.
Muscle & Nerve
Volume 6, Issue 8, pages 574–580, October 1983
How to Cite
Gibson, M. C. and Schultz, E. (1983), Age-related differences in absolute numbers of skeletal muscle satellite cells. Muscle Nerve, 6: 574–580. doi: 10.1002/mus.880060807
- Issue online: 13 OCT 2004
- Version of Record online: 13 OCT 2004
- Manuscript Accepted: 9 JUN 1983
- Manuscript Received: 14 MAR 1983
The absolute number of satellite cells (SC) in young and adult rat skeletal muscle was estimated by correlating data from light and electron microscopic quantitation of myofiber nuclei (myonuclei and satellite cell nuclei) with biochemical assays for determining total muscle DNA content. Expressed both as a proportion of total myofiber nuclei and as absolute numbers, satellite cells are more numerous in the predominantly oxidative soleus muscle than in the mixed glycolytic/oxidative extensor digitorum longus (EDL) muscle at 1, 12, and 24 months of age. Satellite cell proportions decline gradually in both muscles with advancing age, but absolute numbers increase significantly in the soleus between 1 and 12 months, while EDL exhibits a continuous significant decline in satellite cells between each of the ages examined.