Localization of protein kinase C in human skeletal muscle
Article first published online: 13 OCT 2004
Copyright © 1992 John Wiley & Sons, Inc.
Muscle & Nerve
Volume 15, Issue 4, pages 496–499, April 1992
How to Cite
Nakano, S., Shimohama, S., Saitoh, T., Akiguchi, I. and Kimura, J. (1992), Localization of protein kinase C in human skeletal muscle. Muscle Nerve, 15: 496–499. doi: 10.1002/mus.880150414
- Issue published online: 13 OCT 2004
- Article first published online: 13 OCT 2004
- Manuscript Accepted: 9 APR 1991
- protein kinase C;
- human skeletal muscle;
- skeletal muscle
The immunolocalization of protein kinase C (PKC) isozymes α, βI, and βII, was investigated in human skeletal muscle. All three isozymes were present on the muscle fiber surface membrane and within the muscle fibers. The α-isozyme was most clearly delineated on the surface membrane of the muscle fiber and on small blood vessels in the connective tissue. The axons of myelinated intramuscular nerves stained intensely for the βI isozyme, whereas the endoneurial connective tissue reacted more strongly for the α- and βII-isozymes. PKC isozymes may regulate intracellular signal transduction in human skeletal muscle, as in the other tissues. but their exact role in muscle remains unknown.