An animal model of neuropathic pain: A review
Article first published online: 13 OCT 2004
Copyright © 1993 John Wiley & Sons, Inc.
Muscle & Nerve
Volume 16, Issue 10, pages 1040–1048, October 1993
How to Cite
Bennett, G. J. (1993), An animal model of neuropathic pain: A review. Muscle Nerve, 16: 1040–1048. doi: 10.1002/mus.880161007
- Issue published online: 13 OCT 2004
- Article first published online: 13 OCT 2004
- Manuscript Accepted: 29 JAN 1993
- animal models;
- peripheral neuropathy;
- neuropathic pain;
Recent work has succeeded in producing models of painful peripheral neuropathies in laboratory animals. There is evidence that the animals experience both abnormal spontaneous pain and abnormal evoked pains (allodynia and hyperalgesia). Experimental analyses of these models have demonstrated potential pathophysiologic mechanisms in both the peripheral and central nervous systems; it is likely that the model neuropathic pain syndromes are due to several different mechanisms. One line of evidence suggests that these pain states gradually become centralized due to an excitotoxic effect on spinal cord dorsal horn inhibitory interneurons. The role of the sympathetic nervous system appears to vary, depending on the type of nerve injury and the temporal evolution of the syndrome. There is evidence indicating that theabnormality of cutaneous temperature regulation that often accompanies painful peripheral neuropathy is not necessarily due to the activity of sympathetic vasomotor efferents. © 1993 John Wiley & Sons, Inc.