Intestinal pseudo-obstruction in adult spinal muscular atrophy
Article first published online: 13 OCT 2004
Copyright © 1994 John Wiley & Sons, Inc.
Muscle & Nerve
Volume 17, Issue 8, pages 946–948, August 1994
How to Cite
Ionasescu, V., Christensen, J. and Hart, M. (1994), Intestinal pseudo-obstruction in adult spinal muscular atrophy. Muscle Nerve, 17: 946–948. doi: 10.1002/mus.880170816
- Issue published online: 13 OCT 2004
- Article first published online: 13 OCT 2004
- Manuscript Accepted: 16 JAN 1994
- spinal muscular atrophy;
- pseudointestinal obstruction
A 42-Year-old woman sith negative family history had the insidious onset of weakness in her lower extremities 8 years before, in 1983. The disorder slowly progressed to include cramps and muscle twitches. The diagnosis of adult spinal muscular atrophy (SMA) was made when electromyography showed large rapidly firing motor unit potentials, positive waves, and fibrillation potentials, and when muscle biopsy of the quadriceps revealed severe alterations consistent with neurogenic atrophy. The patient also had severe chronic constipation for many years. More recently she had developed unremitting diarrhea. Gastrointestinal studies showed no evidence of peristaltic contractions in the rectum, delayed gastric emptying, and abnormal jejunal manometry with altered propagation of the migrating myoelectrical complex. © 1994 John Wiley & Sons, Inc.