Intrinsic neuromuscular defects in the neurogenic bladder. III. Transjunctional, short- and long-term ultrastructural changes in muscle cells of the decentralized feline bladder base following unilateral sacral ventral rhizotomy

Authors

  • Ahmad Elbadawi,

    Corresponding author
    1. Department of Pathology, SUNY-Upstate Medical Center, Syracuse, New York
    • Department of Pathology, SUNY-Upstate Medical Center, 750 East Adams Street, Syracuse, NY 13210
    Search for more papers by this author
  • Mohamed A. Atta

    1. Department of Pathology, SUNY-Upstate Medical Center, Syracuse, New York
    Search for more papers by this author
    • Assistant Lecturer in Urology, Alexandria University, Egypt, currently on leave as Postgraduate Fellow in Pathology, SUNY-Upstate Medical Center, Syracuse, New York.


Abstract

We have shown previously that vesicourethral decentralization by unilateral sacral ventral rhizotomy in the cat results in sequential degenerative and regenerative ultrastructural changes in intrinsic nerves of the bladder base. The present study in the same model provides evidence that these neural changes are associated with both degenerative and regenerative ultrastructural changes in smooth muscle cells of the feline base, representing the first example of transjunctional postdecentralization change in an effector tissue to be documented in a mammalian autonomically innervated smooth muscle system. The nature of the observed changes in the sarcoplasm, sarcoplasmic organelles, sarcolemma, and cell-to-cell relationships will be discusssed, and their physiologic significance as well as implications in the phenomenon of neurogenic muscular supersensitivity will be presented.

Ancillary