Original Basic Science Article
The effect of tamsulosin on the response of the rabbit bladder to partial outlet obstruction
Article first published online: 19 SEP 2005
Copyright © 2005 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 25, Issue 1, pages 89–94, January 2006
How to Cite
Levin, R. M., Longhurst, P. A., Whitbeck, C. and Korstanje, C. (2006), The effect of tamsulosin on the response of the rabbit bladder to partial outlet obstruction. Neurourol. Urodyn., 25: 89–94. doi: 10.1002/nau.20150
- Issue published online: 20 DEC 2005
- Article first published online: 19 SEP 2005
- Manuscript Accepted: 26 APR 2005
- Manuscript Received: 11 SEP 2004
- Yamanouchi Europe
- Department of Veterans Affairs, Office of Research and Development
- NIH. Grant Number: RO-1-DK067114
- bladder outlet obstruction;
To determine if tamsulosin treatment prevents or decreases the incidence and severity of outlet obstruction-induced bladder dysfunction in rabbits.
Materials and Methods
Male New Zealand White rabbits were treated with tamsulosin or vehicle for 4 weeks with treatments initiated 1 week prior to sham or obstruction surgery. Cystometry was done on anesthetized rabbits 21 days after surgery. The bladders were then removed, weighed, and prepared for in vitro whole bladder studies. Responses to 32 Hz field stimulation (FS), carbachol, phenylephrine, and KCl were measured.
Obstruction resulted in a significant increase in bladder weight, which was unchanged by tamsulosin treatment and a significant increase in micturition pressure in the vehicle-treated group but not in the tamsulosin-treated group. Compliance was significantly decreased in both obstructed groups. The vehicle-treated obstructed rabbits had a very sharp increase in intravesical pressure as the bladder reached capacity; this was not seen in the tamsulosin-treated obstructed rabbits. Tamsulosin did not change the pattern of modifications in contractile responses induced by bladder outlet obstruction.
In vitro responses of vehicle and tamsulosin-treated obstructed rabbit groups in this study were similar. A greater micturition pressure was found for the vehicle-treated obstructed group than for the tamsulosin-treated obstructed group, which was probably due to decreased urethral resistance in the latter. On a functional basis, the higher compliance at capacity and decreased micturition pressure in the tamsulosin-treated obstructed group would be considered beneficial for bladder function. Neurourol. Urodynam. © 2005 Wiley-Liss, Inc.