No conflict of interest reported by the author(s).
Original Clinical Article
Article first published online: 30 MAR 2007
Copyright © 2007 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 26, Issue 6, pages 767–772, October 2007
How to Cite
Suzuki, T., Yasuda, K., Yamanishi, T., Kitahara, S., Nakai, H., Suda, S. and Ohkawa, H. (2007), Randomized, double-blind, sham-controlled evaluation of the effect of functional continuous magnetic stimulation in patients with urgency incontinence. Neurourol. Urodyn., 26: 767–772. doi: 10.1002/nau.20423
Review process led by Rodney Appell, Associate Editor.
- Issue published online: 19 SEP 2007
- Article first published online: 30 MAR 2007
- Manuscript Accepted: 30 JAN 2007
- Manuscript Received: 21 SEP 2006
- magnetic stimulation;
- pelvic floor muscle training (PFMT);
- urodynamic study
To evaluate the effect of functional continuous magnetic stimulation (FCMS) on urgency incontinence in randomized, sham-controlled manner.
Thirty-nine patients with urgency incontinence, 16 males and 23 females (aged 66.0 ± 16.5 years), who were refractory to pelvic floor muscle training (PFMT), were randomly assigned either to the treatment schedule performing 10-week active treatment, followed by 4-week non-treatment interval and then by 10-week sham treatment (A–S, n = 20) or to that performing the sham treatment first followed by 10-week active treatment (S–A, n = 19).
At 10 weeks, the number of leaks/week, the total score of the International Consultation on Incontinence-Questionnaire: Short Form (ICIQ-SF), and maximum cystometric capacity (MCC) were significantly improved as compared with the initial levels (P < 0.001, P < 0.001, and P = 0.003, respectively) in the former group, but not in the latter group. Four (20.0%) patients were cured in the A–S group, while no patient was cured in the S–A group.At the end of the A–S schedule (24 weeks of study), the effect of the active treatment was still maintained at a significantly improved level, as compared with the initial level. At the end of the S–A schedule, the number of leaks/week was significantly improved as compared with the initial level and with its 10-week level (P < 0.001 and P = 0.049, respectively), as well as ICIQ-SF total score (P = 0.001 and P = 0.006, respectively). MCC significantly increased from its initial level (P = 0.030).
Magnetic stimulation was effective on urgency incontinence in comparison to sham stimulation in this small patient group. Neurourol. Urodynam. 26:767–772, 2007. © 2007 Wiley-Liss, Inc.