Conflicts of interest: none.
Article first published online: 18 DEC 2009
Copyright © 2009 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 29, Issue 1, pages 77–81, January 2010
How to Cite
Ustinova, E. E., Fraser, M. O. and Pezzone, M. A. (2010), Cross-talk and sensitization of bladder afferent nerves. Neurourol. Urodyn., 29: 77–81. doi: 10.1002/nau.20817
Christopher Chapple led the review process.
- Issue published online: 18 DEC 2009
- Article first published online: 18 DEC 2009
- Manuscript Accepted: 4 AUG 2009
- Manuscript Received: 8 APR 2009
- NIH. Grant Numbers: DK02488, DK066658
- bladder afferent nerves;
The coordination of pelvic physiologic function requires complex integrative sensory pathways that may converge both peripherally and/or centrally. Following a focal, acute irritative or infectious pelvic insult, these same afferent pathways may produce generalized pelvic sensitization or cross-sensitization as we show bi-directionally for the bladder and bowel in an animal model. Single unit bladder afferent recordings following intracolonic irritation reveal direct sensitization to both chemical and mechanical stimuli that's dependent upon both intact bladder sensory (C-fiber) innervation and neuropeptide content. Concurrent mastocytosis (preponderantly neurogenic) likely plays a role in long-term pelvic organ sensitization via the release of nociceptive and afferent-modulating molecules. Prolonged pelvic sensitization as mediated by these convergent and antidromic reflexive pathway may likewise lead to chronic pelvic pain and thus the overlap of chronic pelvic pain disorders. Neurourol. Urodynam. 29: 77–81, 2010. © 2009 Wiley-Liss, Inc.