Honorary Professor of Urology.
Article first published online: 18 DEC 2009
Copyright © 2009 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 29, Issue 1, pages 30–39, January 2010
How to Cite
de Boer, T.A., Salvatore, S., Cardozo, L., Chapple, C., Kelleher, C., van Kerrebroeck, P., Kirby, M.G., Koelbl, H., Espuna-Pons, M., Milsom, I., Tubaro, A., Wagg, A. and Vierhout, M.E. (2010), Pelvic organ prolapse and overactive bladder. Neurourol. Urodyn., 29: 30–39. doi: 10.1002/nau.20858
Conflicts of interest: All authors except Mrs. T.A. de Boer are members of the Astellas European OAB Faculty. The OAB Faculty is sponsored by Astellas, each author is in receipt of remuneration from the pharmaceutical industry for research and speaking. No assistance, financial, or otherwise was provided for the conception or writing of this article.
Christopher Chapple led the review process.
- Issue published online: 18 DEC 2009
- Article first published online: 18 DEC 2009
- Manuscript Accepted: 26 OCT 2009
- Manuscript Received: 23 OCT 2009
- detrusor overactivity;
- overactive bladder;
- pelvic organ prolapse;
- surgical treatment
In this review we try to shed light on the following questions:
How frequently are symptoms of overactive bladder (OAB) and is detrusor overactivity (DO) present in patients with pelvic organ prolapse (POP) and is there a difference from women without POP?
Does the presence of OAB symptoms depend on the prolapsed compartment and/or stage of the prolapse?
What is the possible pathophysiology of OAB in POP?
Do OAB symptoms and DO change after conservative or surgical treatment of POP?
We searched on Medline and Embase for relevant studies. We only included studies in which actual data about OAB symptoms were available. All data for prolapse surgery were without the results of concomitant stress urinary incontinence (SUI) surgery.
Community- and hospital-based studies showed that the prevalence of OAB symptoms was greater in patients with POP than without POP. No evidence was found for a relationship between the compartment or stage of the prolapse and the presence of OAB symptoms. All treatments for POP (surgery, pessaries) resulted in an improvement in OAB symptoms. It is unclear what predicts whether OAB symptoms disappear or not. When there is concomitant DO and POP, following POP surgery DO disappear in a proportion of the patients. Bladder outlet obstruction is likely to be the most important mechanism by which POP induces OAB symptoms and DO signs. However, several other mechanisms might also play a role.
There are strong indications that there is a causal relationship between OAB and POP. Neurourol. Urodynam. 29: 30–39, 2010. © 2009 Wiley-Liss, Inc.