Conflicts of interest: Dr. Brubaker: Pfizer-Consultant, trial participant, research grant; Allergan-Trial participant, research grant. Dr. Lukacz: Pfizer-Consultant; Proctor & Gamble-Speaker honorarium; Novartis-Speaker honorarium; Watson-Consultant; Intuitive Systems-Consultant. Dr. Burgio: Consultant-Pfizer, Astellas; Trial participant-Astellas. Dr. Leng: Trial participant-Allergan , Research grant-NIH. Dr. Kraus: Consultant-Lilly, Pfizer, Speaker honorarium-Pfizer Novartis; Trial participant-Lilly, Research grant-Lilly.
Original Basic Science Article
Article first published online: 27 MAY 2010
Copyright © 2010 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 30, Issue 1, pages 47–51, January 2011
How to Cite
Brubaker, L., Lukacz, E. S., Burgio, K., Zimmern, P., Norton, P., Leng, W., Johnson, H., Kraus, S. and Stoddard, A. (2011), Mixed incontinence: Comparing definitions in non-surgical patients. Neurourol. Urodyn., 30: 47–51. doi: 10.1002/nau.20922
Heinz Koelbl led the review process.
- Issue published online: 22 DEC 2010
- Article first published online: 27 MAY 2010
- Manuscript Accepted: 9 MAR 2010
- Manuscript Received: 22 SEP 2009
- National Institute of Diabetes and Digestive and Kidney Diseases. Grant Numbers: U01 DK58225, U01 DK58229, U01 DK58234, U01 DK58231, U01 DK60379, U01 DK60380, U01 DK60393, U01 DK60395, U01 DK60397, 60401
- National Institute of Child Health and Human Development and Office of Research in Women's Health
- urge incontinence;
- urinary incontinence;
- mixed incontinence;
- stress incontinence
We aimed to explore operational definitions of mixed urinary incontinence (MUI) for use in incontinence outcomes research for non-surgical patient populations.
A secondary analysis of women with urge incontinence or urge predominant MUI enrolled in the Urinary Incontinence Treatment Network BE-DRI randomized clinical trial was performed. Subjects were characterized at baseline for urinary incontinence severity and incontinence subtype (stress or urge) using the Medical, Epidemiologic, and Social Aspects of Aging (MESA) questionnaire, the Urogenital Distress Inventory, and a 7-day urinary diary. Various different definitions of MUI, ranging from low to high threshold, were created using a combination of these baseline incontinence measures. Prevalence of MUI based on each definition was described and compared to treatment response. Logistic regression analysis was used to estimate the association between the study outcomes and the different definitions of MUI.
The 307 participants in the BE-DRI study had a mean age of 56.9 (±13.9) years with a mean total MESA score of 21.7 (±8.9) and a mean total UDI score of 120.5 (±49.6). The proportion of women diagnosed with MUI varied significantly by definition ranging from 63.5% to 96.4%. Low threshold symptom-based definitions resulted in nearly universal diagnosis of MUI. No strict cut-off value for these baseline measures was identified to predict clinical outcomes.
Current MUI definitions do not adequately categorize clinically relevant UI subgroups. For research purposes we believe it necessary to describe the severity of each incontinence subtype separately in subjects with MUI. Neurourol. Urodyn. 30:47–51, 2011. © 2010 Wiley-Liss, Inc.