Conflicts of interest: none
Original Clinical Article
Article first published online: 23 JUL 2010
Copyright © 2010 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 30, Issue 1, pages 102–107, January 2011
How to Cite
Yamamoto, T., Sakakibara, R., Uchiyama, T., Yamaguchi, C., Nomura, F., Ito, T., Yanagisawa, M., Yano, M., Awa, Y., Yamanishi, T., Hattori, T. and Kuwabara, S. (2011), Pelvic organ dysfunction is more prevalent and severe in MSA-P compared to parkinson's disease. Neurourol. Urodyn., 30: 102–107. doi: 10.1002/nau.20948
Linda Brubaker led the review process.
- Issue published online: 22 DEC 2010
- Article first published online: 23 JUL 2010
- Manuscript Accepted: 22 APR 2010
- Manuscript Received: 5 FEB 2010
- multiple system atrophy;
- Parkinson's disease;
- parkinsonian syndrome;
- pelvic organ dysfunction
It is usually difficult to distinguish between idiopathic Parkinson's disease (PD) and parkinsonian-type multiple system atrophy (MSA-P) in the early stage. However, it is important to make a careful early-stage diagnosis. Therefore, we determined whether an examination of pelvic organ dysfunction would be helpful to distinguish between PD and MSA-P.
We recruited 61 patients with PD and 54 patients with MSA-P who were examined at our neurology clinic. The mean ages of the patients with PD and MSA-P were 67 and 64 years, respectively. The mean disease duration of both groups was 3.2 years. We administered a questionnaire on pelvic organ dysfunction to the PD and MSA-P groups. The questionnaire had sections focusing on bladder, bowel, and sexual function. Dysfunction, as described in the responses, was evaluated as normal, mild (>once a month), moderate (>once a week), or severe (>once a day). The Mann–Whitney U-test was used for statistical analysis.
Compared with the PD group, the prevalence and severity of pelvic dysfunction in the MSA-P group was significantly higher for urinary urgency (MSA-P 76%, PD 58%, P < 0.05), retardation in initiating urination (79%, 48%, P < 0.05), prolongation in urination (79%, 72%, P < 0.05), and constipation (58%, 31%, P < 0.05). The quality-of-life index among pelvic organ dysfunctions indicated that urinary and bowel function was significantly more impaired in the MSA-P group than in the PD group.
Urinary urgency, retardation in initiating urination, prolongation in urination, and constipation are more prevalent and severe in MSA-P compared to PD. Neurourol. Urodyn. 30:102–107, 2011. © 2010 Wiley-Liss, Inc.