Conflict of interest:none.
Original Basic Science Article
Article first published online: 21 SEP 2010
Copyright © 2010 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 30, Issue 1, pages 174–182, January 2011
How to Cite
Vadhavkar, M., Golbidi, S., Sea, J., Longpre, M., Stothers, L. and Laher, I. (2011), Exercise improves bladder function in diabetic mice. Neurourol. Urodyn., 30: 174–182. doi: 10.1002/nau.20964
Lori Birder led the review process.
- Issue published online: 22 DEC 2010
- Article first published online: 21 SEP 2010
- Manuscript Accepted: 24 MAY 2010
- Manuscript Received: 1 FEB 2010
- Heart and Stroke Foundation of Canada
- diabetes mellitus;
- urinary bladder dysfunction;
- urinary incontinence;
- voiding frequency
We determined the effect of exercise on bladder dysfunction and voiding frequency in db/db mice.
Materials and Methods
Diabetic db/db female mice (BKS.Cg-Dock7m +/+ Leprdb/J strain) and their age-matched wild-type controls (WT) were equally divided into sedentary and exercise groups. Mice were exercised for 1 hr everyday for 8 weeks (speed of 5.2 m/min). We performed a voiding pattern test, cystometric analysis and reactivity of isolated bladder strips in WT and db/db mice, both sedentary and exercised.
Diabetes increased the frequency of voiding, bladder capacity, and residual volume. Exercise decreased voiding frequency in db/db mice; voiding frequency was 5.8 ± 0.5 (db/db exercise) versus 10.8 ± 1.1 (db/db control, P < 0.001). In cystometric analysis, the bladder capacity of db/db sedentary mice was 0.27 ± 0.05 ml and was 0.14 ± 0.02 ml in the db/db exercise group (P < 0.05), whereas the residual volume was 0.2 ± 0.03 ml in db/db sedentary mice and 0.06 ± 0.02 ml in db/db Ex mice. Isolated strips of bladder muscle from sedentary db/db mice were more responsive to carbachol than strips from db/db exercise mice. Exercise did not improve the urodynamic properties of WT mice, both sedentary and exercised.
Exercise improves bladder function in diabetic mice by reducing voiding frequency and improving urodynamic parameters. Neurourol. Urodynam. 30:174–182, 2011. © 2010 Wiley-Liss, Inc.