Conflicts of interest: Nothing to declare
Basic Science Paper
Version of Record online: 9 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
Neurourology and Urodynamics
Volume 30, Issue 3, pages 435–437, March 2011
How to Cite
Gualtieri, M., Zhang, Y., Candiotti, K., Yavagal, S., Medina, C. A. and Takacs, P. (2011), The effect of biological and synthetic meshes on vaginal smooth muscle cell proliferation. Neurourol. Urodyn., 30: 435–437. doi: 10.1002/nau.21064
Roger Dmochowski led the review process
- Issue online: 15 MAR 2011
- Version of Record online: 9 FEB 2011
- Manuscript Accepted: 17 DEC 2010
- Manuscript Received: 23 NOV 2010
- smooth muscle cells;
To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation.
Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular collagen matrix mesh exposed cells compared to the type I polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.03 vs. 0.21 ± 0.01, P = 0.03). Under estradiol supplementation cell proliferation in the porcine mesh exposed cells remained significantly higher compared to the polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.04 vs. 0.15 ± 0.03, P < 0.01).
The decreased rate of erosion found with the utilization of biological absorbable mesh in vaginal reconstructive surgery may partially be explained by the significantly increased VaSMC proliferation with porcine dermal acellular collagen mesh compared to polypropylene mesh. Neurourol. Urodynam. 30:435–437, 2011. © 2011 Wiley-Liss, Inc.