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Increased serum nerve growth factor levels in patients with overactive bladder syndrome refractory to antimuscarinic therapy

Authors

  • Hsin-Tzu Liu,

    1. Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    2. Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan
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  • Heng Lin,

    1. Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan
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  • Hann-Chorng Kuo

    Corresponding author
    1. Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
    • Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, 707, Section 3, Chung-Yang Road, Hualien, Taiwan.
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  • Karl-Erik Andersson led the review process.

  • Conflict of interest: none.

Abstract

Objective

To investigate the serum nerve growth factor (NGF) and urinary NGF levels in patients with overactive bladder syndrome (OAB) refractory to antimuscarinic therapy.

Materials and Methods

Thirty-four patients with OAB (17 OAB-dry and 17 OAB-wet) and 31 normal subjects were enrolled. The patients were diagnosed to have OAB based on symptoms of urgency with/without urgency incontinence and 3-day voiding diary. All OAB patients had been treated with previous antimuscarinic therapy for at least 3 months but had failed. Serum and urine were collected at baseline and after solifenacin treatment for 3 months. The serum NGF and urinary NGF levels were compared between OAB-dry and OAB-wet and between baseline and after solifenacin treatment.

Results

Serum NGF levels were significantly elevated in OAB (median and interquartile range, 7.367 pg/ml, 0–57.66) compared to the controls (0.0728 pg/ml, 0–0.234, P < 0.001). Urinary NGF/Cr levels were significantly elevated in patients with OAB (0.685 pg/mg, 0.08–1.94) compared to the controls (0.005 pg/mg, 0–0.0275, P < 0.001). Serum NGF levels were significantly correlated with urinary NGF (P = 0.002) and NGF/Cr levels (P < 0.001) in OAB patients. There was no significant difference of serum NGF levels between OAB-dry and OAB-wet. The serum and urinary NGF levels remained unchanged (P = 0.504 and 0.414, respectively) in OAB patients after solifenacin therapy. The serum NGF levels were highly correlated between baseline and after solifenacin treatment (R2 = 0.83, P < 0.001).

Conclusions

Increased serum and urinary NGF levels in patients with OAB refractory to antimuscarinic treatment suggest these bladder disorders might be caused by chronic inflammation. Neurourol. Urodynam. Neurourol. Urodynam. 30: 1525–1529, 2011. © 2011 Wiley Periodicals, Inc.

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