Conflict of interest: none.
Original Basic Science Article
Version of Record online: 28 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 31, Issue 1, pages 99–104, January 2012
How to Cite
Lei, D., Ma, J., Du, X., Shen, G., Tian, M. and Li, G. (2012), Spontaneous brain activity changes in children with primary monosymptomatic nocturnal enuresis: A resting-state fMRI study. Neurourol. Urodyn., 31: 99–104. doi: 10.1002/nau.21205
Dirk De Ridder led the review process.
- Issue online: 23 JAN 2012
- Version of Record online: 28 OCT 2011
- Manuscript Accepted: 12 JUL 2011
- Manuscript Received: 8 MAY 2011
- Science and Technology Commission of Shanghai. Grant Number: 08DZ1900702
- Shanghai Children's Medical Center Fund
- Shanghai Key Laboratory of Children's Environmental Health. Grant Numbers: 10DZ2272200, 09DZ2200900
- Development of Science and Technology Fund of Pudong New Area, Shanghai. Grant Number: PKJ2009-Y03
- resting-state fMRI
Primary monosymptomatic nocturnal enuresis (PMNE) is a common disorder in school-aged children. However, little is known about resting-state neural function in individuals with PMNE. In this work, resting-state functional magnetic resonance imaging (fMRI) was used to investigate changes in spontaneous brain activity in children with PMNE. We analyzed resting-state fMRI data using statistical parametric mapping (SPM) and a resting-state fMRI data analysis toolkit (REST). Regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) values were calculated to analyze spontaneous brain activity in 16 children with PMNE and 16 healthy controls. Children with PMNE exhibited significant differences in ALFF or ReHo in the left inferior frontal gyrus, medial frontal gyrus (Brodmann area, BA 10), and left midbrain. Abnormalities in BA 10 and the inferior frontal gyrus may affect children's decision-making with regard to voiding; abnormalities in the midbrain in PMNE children may influence the internal signal transmission in their bladder control network. Our data indicate that, in children with PMNE, several brain areas related to the micturate control network undergo developmental delay. Neurourol. Urodynam. 31:99–104, 2012. © 2011 Wiley Periodicals, Inc.