Lori Birder led the review process.
Original Basic Science Article
Version of Record online: 28 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 31, Issue 1, pages 178–184, January 2012
How to Cite
Zeng, J., Xie, K., Jiang, C., Mo, J. and Lindström, S. (2012), Bladder mechanoreceptor changes after artificial bladder outlet obstruction in the anesthetized rat. Neurourol. Urodyn., 31: 178–184. doi: 10.1002/nau.21219
The authors declare that they have no conflict of interest.
- Issue online: 23 JAN 2012
- Version of Record online: 28 OCT 2011
- Manuscript Accepted: 23 AUG 2011
- Manuscript Received: 22 JUN 2011
- Swedish Medical Research Council
- Qingyuan City People's Hospital of Jinan University, China
- residual urine
Experimental animal models of bladder outlet obstruction (BOO) have reproduced several features of BOO in man, i.e., detrusor hypertrophy, instability, frequency, and residual urine. This study was focused on the mechanisms underlying the development of residual urine in patient with benign prostatic hyperplasia (BPH) by examining changes in tension sensitivity of bladder mechanoreceptors in rat model.
Female adult Sprague-Dawley rats including 12 BOO and 17 sham operated rats were used in this study. Cystometrograms together with the bladder afferent activity were recorded. Tension sensitivity of the afferents was determined by plotting the normalized afferent response against the contraction evoked bladder pressure at different volumes. Degree of obstruction was assessed by the wet weight of the bladder at the end of the experiment.
The bladder weight, maximal bladder capacity, micturition threshold volume, peak contraction force, and volume at peak contraction force were all significantly increased in obstructed animals. The threshold volume for afferent activation was increased (mean 0.60 ml compared to 0.15 ml in controls; P < 0.001), positively correlated with the bladder weight (r = 0.74). The tension sensitivity of the bladder mechanoreceptors and the slope of their normalized pressure-response functions were significantly lower at the comparable volumes in the obstructed animals.
Rats with BOO had bladder mechanoreceptors with higher threshold volumes and lower tension sensitivity. Such changes would result in a weaker afferent drive of the micturition reflex. Similar changes may contribute to the development of residual urine and retention in patients with BOO. Neurourol. Urodynam. 31:178–184, 2012. © 2011 Wiley Periodicals, Inc.