Does patient age impact outcomes of neuromodulation?

Authors


  • Eric Rovner led the peer-review process as the Associate Editor responsible for the paper.

  • Kenneth M. Peters discloses that he is a consultant for Medtronic on future technologies.

Abstract

Aims

We evaluated whether patients stratified by age have the same level of risks/benefits after a staged neuromodulation procedure for refractory voiding symptoms.

Methods

Urologic diagnosis, complications, and revisions were collected from medical records of adults enrolled in our prospective observational study. Symptoms were assessed over 2 years with diaries, Interstitial Symptom-Problem Indices (ICSI-PI), and the Overactive Bladder Questionnaire-SF (OAB-q SF). 12-item Short-Form Health Survey (SF-12v2®) mental (MCS) and physical (PCS) component summaries evaluated quality of life. Data were examined with Pearson Chi-square or Fisher's Exact test, Kruskal-Wallis tests, and repeated measures analyses.

Results

Patients (83% female) were grouped by age (years): <40 (n = 46), 40–64 (n = 146), and ≥65 (n = 136). Urge incontinence was predominant in the older groups and more patients <40 had interstitial cystitis/painful bladder syndrome (IC/PBS). In the <40, 40–64, and ≥65 groups, respectively, generator implant (91%, 88%, and 89%) and explant (15%, 12%, and 10%) rates were similar. Complications (24%, 14%, and 9%; P = 0.031) and revisions (20%, 5%, and 6%; P = 0.0025) differed. For the three respective groups, urinary frequency (P < 0.0001 for all), nocturia (P < 0.0001 for all), incontinence episodes (P < 0.0001 for all), urgency (P = 0.0474, P < 0.0001, P = 0.0020), ICSI-PI (P = 0.0015, P < 0.0001, P < 0.0001), and OAB-q scores improved over time. Incontinence severity improved in those >65 (P = 0.0015). SF-12 PCS improved in those 40–64 (P = 0.0482) and MCS scores improved in the <40 and 40–64 age groups (P = 0.013 and P = 0.0440, respectively).

Conclusions

These data suggest that neuromodulation success is not age dependent, however continued study is needed to confirm findings. Neurourol. Urodynam. 32: 30–36, 2013. © 2012 Wiley Periodicals, Inc.

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