Eric Rovner led the peer-review process as the Associate Editor responsible for the paper.
Original Clinical Article
Article first published online: 5 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 32, Issue 1, pages 30–36, January 2013
How to Cite
Peters, K. M., Killinger, K. A., Gilleran, J. and Boura, J. A. (2013), Does patient age impact outcomes of neuromodulation?. Neurourol. Urodyn., 32: 30–36. doi: 10.1002/nau.22268
Kenneth M. Peters discloses that he is a consultant for Medtronic on future technologies.
- Issue published online: 18 DEC 2012
- Article first published online: 5 JUN 2012
- Manuscript Accepted: 19 APR 2012
- Manuscript Received: 27 JAN 2012
- Ministrelli Program for Urology Research and Education (MPURE)
- electrical stimulation therapy;
- urinary bladder;
- urination disorders
We evaluated whether patients stratified by age have the same level of risks/benefits after a staged neuromodulation procedure for refractory voiding symptoms.
Urologic diagnosis, complications, and revisions were collected from medical records of adults enrolled in our prospective observational study. Symptoms were assessed over 2 years with diaries, Interstitial Symptom-Problem Indices (ICSI-PI), and the Overactive Bladder Questionnaire-SF (OAB-q SF). 12-item Short-Form Health Survey (SF-12v2®) mental (MCS) and physical (PCS) component summaries evaluated quality of life. Data were examined with Pearson Chi-square or Fisher's Exact test, Kruskal-Wallis tests, and repeated measures analyses.
Patients (83% female) were grouped by age (years): <40 (n = 46), 40–64 (n = 146), and ≥65 (n = 136). Urge incontinence was predominant in the older groups and more patients <40 had interstitial cystitis/painful bladder syndrome (IC/PBS). In the <40, 40–64, and ≥65 groups, respectively, generator implant (91%, 88%, and 89%) and explant (15%, 12%, and 10%) rates were similar. Complications (24%, 14%, and 9%; P = 0.031) and revisions (20%, 5%, and 6%; P = 0.0025) differed. For the three respective groups, urinary frequency (P < 0.0001 for all), nocturia (P < 0.0001 for all), incontinence episodes (P < 0.0001 for all), urgency (P = 0.0474, P < 0.0001, P = 0.0020), ICSI-PI (P = 0.0015, P < 0.0001, P < 0.0001), and OAB-q scores improved over time. Incontinence severity improved in those >65 (P = 0.0015). SF-12 PCS improved in those 40–64 (P = 0.0482) and MCS scores improved in the <40 and 40–64 age groups (P = 0.013 and P = 0.0440, respectively).
These data suggest that neuromodulation success is not age dependent, however continued study is needed to confirm findings. Neurourol. Urodynam. 32: 30–36, 2013. © 2012 Wiley Periodicals, Inc.