Roger Dmochowski led the peer-review process as the Associate Editor responsible for the paper.
Original Clinical Article
Article first published online: 5 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 32, Issue 3, pages 271–275, March 2013
How to Cite
Kang, J.-H., Keller, J. J., Chen, Y.-K. and Lin, H.-C. (2013), Reflux esophagitis increased the risk of bladder pain syndrome/interstitial cystitis: A 3-year follow-up study. Neurourol. Urodyn., 32: 271–275. doi: 10.1002/nau.22270
Conflict of interest: none.
Jiunn-Horng Kang and Joseph Keller contributed equally to this work.
- Issue published online: 18 MAR 2013
- Article first published online: 5 JUN 2012
- Manuscript Accepted: 19 APR 2012
- Manuscript Received: 2 MAR 2012
- bladder pain syndrome/interstitial cystitis;
- interstitial cystitis;
- reflux esophagitis
Reflux esophagitis (RE) is a common disease which has been recognized to be associated with several medical co-morbidities. However, the association between RE and bladder pain syndrome/interstitial cystitis (BPS/IC) is still unknown. The present study aimed to explore the association between these two diseases.
We identified 8,962 female patients who had received a diagnosis of RE as the study cohort. We randomly selected 44,810 subjects to be included as the comparison cohort. Each patient in this study was individually tracked for a 3-year period to identify those who subsequently received a diagnosis of BPS/IC. Cox proportional hazards regressions were carried out to estimate the 3-year risk of BPS/IC following a diagnosis of RE.
The incidence of BPS/IC following a diagnosis of RE was 4.3% during the follow-up period for all subjects. The incidence rate of BPS/IC was 2.38 [95% confidence interval (CI): 2.21–2.57] per 100 person-years in patients with RE, and 1.24 (95% CI: 1.18–1.30) per 100 person-years in controls. Cox proportional analysis indicated that the hazard ratio (HR) of BPS/IC for patients with RE was 2.00 (95% CI = 1.82–2.20, P < 0.001) that of controls. The adjusted HR of BPS/IC for patients with RE was 1.40 (95% CI = 1.27–1.55, P < 0.001) after taking age group, urbanization level, and medical comorbidity into consideration.
We found that patients with RE were at a higher risk than with comparison patients for having been subsequently diagnosed with BPS/IC during longitudinal follow-up. Neurourol. Urodynam. 32: 271–275, 2013. © 2012 Wiley Periodicals, Inc.