Karl-Erik Andersson led the peer-review process as the Associate Editor responsible for the paper.
Original Basic Science Article
Article first published online: 5 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 32, Issue 1, pages 98–103, January 2013
How to Cite
Oyama, T., Kawai, Y. and Oka, M. (2013), Tramadol enhances urethral continence function through µ-opioid receptors in rats. Neurourol. Urodyn., 32: 98–103. doi: 10.1002/nau.22274
Conflict of interest: none.
- Issue published online: 18 DEC 2012
- Article first published online: 5 JUN 2012
- Manuscript Accepted: 24 APR 2012
- Manuscript Received: 25 JAN 2012
- stress urinary incontinence;
(±)-Tramadol hydrochloride (tramadol) is a widely used analgesic that stimulates the µ-opioid receptor and inhibits the reuptake of serotonin and noradrenalin. Although tramadol is also known to inhibit the micturition reflex in rats, its effects on urethral continence function have not been reported. We therefore examined whether intravenous tramadol (1, 3, and 10 mg/kg) affects intraurethral pressure, bladder leak point pressure, and leak volume in urethane-anesthetized female rats.
(1) The intraurethral pressure was recorded with a microtip pressure transducer placed at the maximum pressure zone of the intrinsic urethral sphincter. (2) Gentle pressure was directly applied to the saline-filled bladder with a cotton bud until leakage occurred, and the bladder pressure at the moment of leakage was taken as the bladder leak point pressure. (3) The leak volume was measured as the amount of fluid leakage from the urethral orifice after electrical stimulation of abdominal muscles.
Tramadol significantly increased the intraurethral pressure. Both tramadol and morphine increased the bladder leak point pressure and decreased the leak volume. These changes were reversed by subcutaneous pretreatment with naloxone.
Tramadol improved urethral function and inhibited urinary incontinence through µ-opioid receptors. Neurourol. Urodynam. 32: 98–103, 2013. © 2012 Wiley Periodicals, Inc.