Lori Birder led the peer-review process as the Associate Editor responsible for the paper.
Original Basic Science Article
Article first published online: 5 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 32, Issue 3, pages 293–300, March 2013
How to Cite
Chen, S.-C., Lai, C.-H., Fan, W.-J. and Peng, C.-W. (2013), Pudendal neuromodulation improves voiding efficiency in diabetic rats. Neurourol. Urodyn., 32: 293–300. doi: 10.1002/nau.22280
Conflicts of interest: none.
Shih-Ching Chen, Chien-Hung Lai contributed equally to this work and should be considered as first authors.
- Issue published online: 18 MAR 2013
- Article first published online: 5 JUN 2012
- Manuscript Accepted: 15 MAY 2012
- Manuscript Received: 10 JAN 2012
- National Science Council, Taiwan, R.O.C.. Grant Numbers: NSC98-2221-E-038-005-MY2, NSC100-2320-B-038-003-MY3
- diabetes mellitus;
- electrical stimulation;
- urinary bladder
Diabetic cystopathy is typically manifested as bladder voiding dysfunction, and numerous patients are refractory to standard therapy. In this study, we determined whether electrical stimulation (ES) of the sensory branch of the pudendal nerve could engage an augmenting reflex and thereby improve bladder emptying in a diabetic animal model with cystopathy.
The efficiency of bladder emptying with ES of the sensory branch of the pudendal nerve at different stimulation intensities was measured in rats at 8 or 18 weeks after the induction of diabetes with streptozotocin.
The voiding efficiency (VE) was reduced from 74 ± 4% to 30 ± 8% in rats with diabetes for 8 weeks and from 73 ± 6% to 20 ± 6% in rats with diabetes for 18 weeks. ES at lower intensities (0.025–0.05 mA) applied to the pudendal sensory nerve did not affect the VE in rats with diabetes for 18 weeks but increased the VE in rats with diabetes for 8 weeks. Subsequently, when the stimulation intensity was elevated to 0.1–0.3 mA, the VEs in rats with diabetes for both 8 and 18 weeks increased to 40–50%.
The results of the present study are consistent with the essential role for pudendal sensory feedback in efficient bladder emptying, and electrical activation of the sensory branch of the pudendal nerve was efficient restoring the voiding function in diabetic animals with cystopathy. This could provide an approach to improve bladder emptying in diabetic patients with voiding dysfunction. Neurourol. Urodynam. 32: 293–300, 2013. © 2012 Wiley Periodicals, Inc.