Heinz Koelbl led the peer-review process as the Associate Editor responsible for the paper.
Original Clinical Article
Article first published online: 20 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 32, Issue 4, pages 383–386, April 2013
How to Cite
Gilchrist, A. S., Campbell, W., Steele, H., Brazell, H., Foote, J. and Swift, S. (2013), Outcomes of observation as therapy for pelvic organ prolapse: A study in the natural history of pelvic organ prolapse. Neurourol. Urodyn., 32: 383–386. doi: 10.1002/nau.22298
Conflict of interest: none.
- Issue published online: 15 APR 2013
- Article first published online: 20 AUG 2012
- Manuscript Accepted: 11 JUL 2012
- Manuscript Received: 23 APR 2012
- natural history;
To determine the rate of progression or regression of pelvic organ prolapse (POP) in subjects with symptomatic POP who decline intervention (pessary or surgery) and elect observation.
Sixty-four patients choosing observation as primary management of symptomatic POP were followed with sequential pelvic organ prolapse quantification (POP-Q) exams. A change in the leading edge value of ±≥2 cm was considered significant. POP-Q exam results, choice of therapy and symptom severity at last visit were recorded.
The leading vaginal edge POP-Q exam value at initial exam ranged from −1.5 to 7 cm. Distribution of patients by POP-Q stages on initial exam was: stage I: 1%, stage II: 31%, stage III: 31%, and stage IV: 1.78% (50/64) of patients demonstrated no change in leading edge value from first to last visit on POP-Q exams. Nineteen percent (12/64) demonstrated progression (≥2 cm increase in leading edge); 3% (2/64) demonstrated regression (≥2 cm decrease in leading edge). Median follow-up was 16 months (range 6–91 months). On multivariate analysis, no variable, including length of follow-up, was associated with change in leading edge value (P = 0.09, data not shown). At their last recorded visit, 63% (40/64) of subjects continued observation, 38% (24/64) desired a pessary trial or surgical correction. Those desiring intervention had no greater worsening of prolapse on exam at last follow-up compared with subjects who continued observation.
The natural history of pelvic organ prolapse is most often one of very minimal change in subjects who decline intervention (pessary or surgery) and choose observation. Neurourol. Urodynam. 32: 383–386, 2013. © 2012 Wiley Periodicals, Inc.