Karl-Erik Andersson led the peer-review process as the Associate Editor responsible for the paper.
Original Basic Science Article
Version of Record online: 12 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 32, Issue 3, pages 276–280, March 2013
How to Cite
Teitsma, C. A., de la Rosette, J. J.M.C.H. and Michel, M. C. (2013), Are polymorphisms of the β3-adrenoceptor gene associated with an altered bladder function?. Neurourol. Urodyn., 32: 276–280. doi: 10.1002/nau.22305
Teitsma reports no conflict of interest. JJMCH de la Rosette reports relationships with BSC, Lilly, and AMS. MC Michel reports relationships with Allergan, AltheRX, Astellas, Bayer, Boehringer Ingelheim, and Pfizer.
- Issue online: 18 MAR 2013
- Version of Record online: 12 SEP 2012
- Manuscript Accepted: 8 AUG 2012
- Manuscript Received: 11 JUN 2012
- Astellas Europe B.V.
- Coordination Theme 1 (Health) of the European Community's FP7. Grant Number: HEALTH-F2-2008-223234
- bladder function;
- gene polymorphism
As the presence of a Trp64Arg polymorphism of the gene encoding the β3-adrenoceptor (B3AR) has been linked to the presence of overactive bladder, we investigated whether additional polymorphisms are detectable in this gene and explore their relationships parameters related to lower urinary tract function.
The coding region and adjacent stretches of the B3AR gene was sequenced in 91 patients. In total, 1015 patients from a single academic hospital were genotyped for the presence of two single nucleotide polymorphisms. Symptom scores and parameters from pressure-flow studies were analyzed relative to genotype in the B3AR gene.
No frequent novel polymorphisms were detected in the coding region. Five polymorphisms were found in the non-coding region of the gene but were in complete linkage with the 64Arg allele. Out of 32 parameters including bladder compliance, only prostate size was weakly (44 vs. 39 mL) but significantly associated with the 64Arg allele, but was not mirrored by an association with prostate-specific antigen levels.
Our data do not support the hypothesis that polymorphisms in the B3AR gene are associated with alterations of bladder function. Neurourol. Urodynam. 32: 276–280, 2013. © 2012 Wiley Periodicals, Inc.