Conflict of Interest: The authors are employees of Ferring Pharmaceuticals.
Original Clinical Article
Version of Record online: 12 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 32, Issue 4, pages 363–370, April 2013
How to Cite
Juul, K. V., Klein, B. M. and Nørgaard, J. P. (2013), Long-term durability of the response to desmopressin in female and male nocturia patients. Neurourol. Urodyn., 32: 363–370. doi: 10.1002/nau.22306
Christopher Chapple led the peer-review process as the Associate Editor responsible for the paper.
- Issue online: 15 APR 2013
- Version of Record online: 12 SEP 2012
- Manuscript Accepted: 8 AUG 2012
- Manuscript Received: 18 MAY 2012
- Ferring Pharmaceuticals
To explore the durability of efficacy and gender differences during chronic administration of desmopressin in nocturia.
This pooled analysis of three short-term efficacy studies, with extensions, of desmopressin administered as orally disintegrating tablet (ODT) or solid tablet in nocturia treatment, comprised 351 patients completing 40–56 weeks' treatment. Efficacy endpoints of change in number of nocturnal voids and duration of initial undisturbed sleep period from baseline were analyzed to determine response durability and gender differences.
The mean decrease in number of nocturnal voids during short-term treatment was maintained and further reduced during the long term. At 52 weeks, the mean decrease in number of nocturnal voids from baseline reached 1.4–2.1 voids for desmopressin ODT 25–100 µg. Following 40-week tablet treatment, the decrease in number of nocturnal voids was 0.8–1.5 for desmopressin 100–400 µg. The mean decrease in nocturnal voids (25–50 µg ODT) was greater for females than males. For females, the improvement in initial period of undisturbed sleep was 2.5–3 hr for desmopressin ODT 25–100 µg, compared with 1.3–2.6 hr for males. No gender difference in efficacy was seen in the tablet studies.
The decrease in nocturnal voids and improvement in sleep with short-term desmopressin treatment were maintained throughout long-term treatment. A durable gender difference in efficacy in favor of females was observed with desmopressin ODT 25 µg. Further, large-scale long-term trials are needed to confirm the durability of efficacy with gender-specific doses of desmopressin. Neurourol. Urodynam. 32: 363–370, 2013. © 2012 Wiley Periodicals, Inc.