We analyzed our original experimental studies on which the midurethral sling was based with reference to FDA mesh warnings.
We concluded that
- 1.Vascular/organ damage could be avoided by first penetrating the urogenital diaphragm.
- 2.A non-stretch tape minimizes obstruction and urethral damage.
- 3.A non-obstructive musculoelastic mechanism closes the urethra.
- 4.The strength of neocollagen (>92.8 lbs/sq inch) indicates that little mesh is required for prolapse repair.
- 5.Foreign body (mesh) reaction is different from infection and is related to volume implanted
- 6.Urgency is potentially curable by repairing the suspensory ligaments
- 7.“Minislings” are promising for incontinence and POP, but more development is required.
Neurourol. Urodynam. 32: 399–406, 2013. © 2012 Wiley Periodicals, Inc.